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How to secure AI infrastructure: Best practices

By Jerald Murphy

AI and generative AI represent great opportunities for enterprise innovation, but as these tools become more prevalent, their attack surfaces attract malicious hackers probing potential weaknesses. The same capabilities that enable AI to transform industries also make it a lucrative target for malicious actors.

Let's examine why constructing a secure AI infrastructure is so important and then jump into key security best practices to help keep AI safe.

Top AI infrastructure security risks

Among the risks companies face with their AI systems are the following:

Addressing these risks requires comprehensive and proactive strategies tailored to AI infrastructure.

How to improve the security of AI environments

While AI applications show amazing promise, they also expose major security flaws. Recent reports highlighting DeepSeek's security vulnerabilities only scratch at the surface; most generative AI (GenAI) systems exhibit similar weaknesses. To properly secure AI infrastructure, enterprises should follow these best practices:

Implement zero trust

Zero trust is a foundational approach to secure AI infrastructure. This framework operates on the principle of "never trust, always verify," ensuring all users and devices accessing resources are authenticated and authorized. Zero-trust microsegmentation minimizes lateral movement within the network, while other zero-trust processes enable companies to monitor networks and flag any unauthorized login attempts to detect anomalies.

Secure the data lifecycle

AI systems are only as secure as the data they ingest, process and output. Key AI data security actions include the following:

Harden AI models

Take the following steps to protect the integrity and confidentiality of AI models:

Monitor AI-specific threats

Traditional monitoring tools might not capture AI-specific threats. Invest in specialized monitoring that can detect the following:

Several companies, including IBM, SentinelOne, Glasswall and Wiz, offer tools and services designed to detect and mitigate AI-specific threats.

Secure the supply chain

AI infrastructure often depends on third-party components, from open-source libraries to cloud-based APIs. Best practices to secure the AI supply chain include the following:

Maintain strong API security

APIs underpin AI systems, enabling data flow and external integrations. To help secure AI infrastructure, use API gateways to authenticate, rate-limit and monitor. In addition, implement OAuth 2.0 and TLS for secure communications. Finally, regularly test APIs for vulnerabilities, such as broken authentication or improper input validation.

Ensure continuous compliance

AI infrastructure often combs through and relies on sensitive data subject to regulatory requirements, such as GDPR, CCPA and HIPAA. Do the following to automate compliance processes:

Keep in mind that compliance is necessary, but the process in and of itself is insufficient in helping companies protect their AI infrastructure.

As AI and GenAI continue to proliferate, security is a key concern. Use a multilayered approach to protect data and models and to secure APIs and supply chains. Implement best practices and deploy advanced security technologies. These steps will help CISOs and security teams protect their AI infrastructure against evolving threats. The time to act is now.

Jerald Murphy is senior vice president of research and consulting with Nemertes Research. With more than three decades of technology experience, Murphy has worked on a range of technology topics, including neural networking research, integrated circuit design, computer programming and global data center design. He was also the CEO of a managed services company.

14 Mar 2025

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